This paper describes research relating to the major recall of pet food that occurred in Spring 2007 in North America. Clinical observations of acute renal failure in cats and dogs were associated with consumption of wet pet food produced by a contract manufacturer producing for a large number of companies.
Identification and Characterization of Toxicity of Contaminants in Pet Food Leading to an Outbreak of Renal Toxicity in Cats and Dogs
This non-destructive optical technique can provide a rapid measurement of sample biochemistry and identify variations that occur between healthy and diseased tissues. The advantage of this method is that it is objective and provides reproducible diagnosis, independent of fatigue, experience and inter-observer variability.
Infrared micro-spectral imaging: distinction of tissue types in axillary lymph node histology
A recent study has demonstrated that the accuracy of kidney stone diagnosis can be substantially improved by switching from conventional optical microscopy and contrast staining to infrared (IR) microspectroscopy.
Infrared Microscopy Provides More Accurate Kidney Stone Diagnosis
Discussion of state-of-the-art methodology for the collection and analysis of hyperspectral images of tissue that will become useful in complementing classical histopathology.
Infrared spectral imaging of lymph nodes: Strategies for analysis and artifact reduction
Examination of the effects of boric acid on human skin melanoma cells using synchrotron FTIR imaging (FTIRI) with a Focal Plane Array (FPA) detector and Point Spread Function (PSF) image deconvolution.
Assessment of the Chemical and Morphological Changes Induced in Cells by Boric Acid treatment using High Resolution Infrared Imaging
Thermo Scientific Nicolet iN10 MX FT-IR Microscope
Thermo Scientific Nicolet iN10 FT-IR Microscope
We report infrared (IR) spectra observed for individual, cultured human cervical cancer (HeLa) cells. Spectra were collected microscopically, in reflection/absorption modes, from cells deposited and dried on microscope slides or from cells grown directly on slides. The results reported here confirm earlier findings and present the possibility of determining the abundance of cells within each stage of the cycle from the IR spectra.
Infrared Microspectroscopy of Individual Human Cervical Cancer (HeLa) Cells
Paint samples received by forensic laboratories are usually in the form of small chips or smears. Infrared (IR) spectroscopy is one of the most commonly used tools available for the analysis of these types of samples and serves as a staple comparative technique in the assessment of whether or not a questioned sample could have come from a suspected object.
Standard Guide for Using Infrared Spectroscopy in Forensic Paint Examinations
Oral epithelial tumour tissue, and cultured cervical epithelial carcinoma cells have been studied using synchrotron infrared microspectroscopy. These results go some way to demonstrate the potential of infrared spectroscopy as a tool in the post-operative screening of oral cancer patients by the examination of exfoliated epithelial cells.
Infrared microscopy of epithelial cancer cells in whole tissues and in tissue culture, using synchrotron radiation
We isolated whole cancer cell nuclei and obtained, for the first time, their FTIR spectra with good signal to noise ratio. The synchrotron-based FTIR (S-FTIR) spectra of nuclei showed changes in lipids, proteins, and DNA absorptions when compared to spectra of whole lung cancer cells.
Spectroscopic signatures of single, isolated cancer cell nuclei using synchrotron infrared microscopy
In the present study we demonstrate, for the first time, the differences in biomolecular localizations observed in SR-FTIR images of cells fixed by formalin, formalin–critical point drying (CPD), and glutaraldehyde–osmium tetroxide–CPD, using the PC-3 prostate cancer cell line.
Fixation protocols for subcellular imaging by synchrotron-based Fourier transform infrared microspectroscopy
Using IR microspectroscopy, an integrated ‘biochemical-cell fingerprint’ of the lipid, protein and carbohydrate composition of a biomolecular entity may be derived in the form of a spectrum via vibrational transitions of individual chemical bonds. Powerful statistical approaches (e.g. principal component analysis) now facilitate the interrogation of large amounts of spectroscopic data to allow the extraction of what may be small but extremely significant biomarker differences between disease-free and pre-malignant or malignant samples.
IR microspectroscopy: potential applications in cervical cancer screening